The main oral factor Xa inhibitors are rivaroxaban, apixaban, edoxaban, and betrixaban. These drugs, also known as direct oral anticoagulants (DOACs) or novel oral anticoagulants (NOACs), work by directly inhibiting factor Xa, a key player in the blood clotting cascade. 

Here’s a more detailed look:

• Rivaroxaban:(Brand name: Xarelto) It is a reversible direct factor Xa inhibitor.Â
• Apixaban:(Brand name: Eliquis) It’s a reversible oral, small molecule inhibitor of factor Xa.Â
• Edoxaban:(Brand name: Savaysa) It’s another orally administered direct factor Xa inhibitor.Â
• Betrixaban:(Brand name: Bevyxxa) It’s an orally administered direct factor Xa inhibitor used for the prophylaxis of venous thromboembolism in hospitalized patients.Â